Shinsuke Niwa

This study identifies Kif2C as a critical regulator of radial glial cell integrity, showing its role in preventing cortical malformations and linking its dysfunction to human neurodevelopmental disorders.

The paper identifies KLP-6 as a kinesin-3 resistant to ADP inhibition, showing its unique ATP selectivity through sequence and molecular dynamics analysis.

The paper shows UNC-83 isoforms differentially regulate kinesin-1 and dynein to control nuclear migration directionality during development.

This study identifies SLC-25A46 as a regulator of mitochondrial fusion through FZO-1/Mitofusin and shows its role in maintaining neuronal morphology.

This study presents cryo-EM structures of GAS2 domains bound to actin and microtubules, revealing their roles in cytoskeletal organization and dimerization.

The paper develops a photostable DNA block to study how a pathogenic kinesin mutant affects collective transport with wild-type kinesin, revealing velocity dynamics.

This study shows that the monomeric kinesin-3 motor KLP-6 moves processively along microtubules via its tail domain, explained by a Brownian ratchet model involving conformational changes rather than asymmetric potentials.

The paper investigates the role of the FHA domain in regulating dimerization of DmUNC-104 and links abnormal dimerization to human diseases.

This study shows that Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA, reclassifying it as a processive and dimeric motor.

This study shows Kif23 is essential for proper cytokinesis and neural stem/progenitor cell maintenance in developing mouse and human neocortex, with its disruption leading to microcephaly-like phenotypes.