Author

David W. Holden

Imperial College LondonORCID 0000-0002-8369-5105Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Mei LiuiD· 2 shared Alexander V. PredeusiD· 1 shared Andrea MajstorovićiD· 1 shared Blanca M. Perez-SepulvedaiD· 1 shared Hai Xia XieiD· 1 shared Jay C. D. HintoniD· 1 shared Romina TocciiD· 1 shared Ruhong Hou· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Mei LiuORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintApr 23, 2025

Salmonella SteD and mammalian SUSD6 use TMEM127 to co-disinhibit the WWP2 E3 ubiquitin ligase

Samkeliso V. Blundell, Mei Liu, Romina Tocci…·David W. Holden

The paper shows that TMEM127 and SUSD6, along with Salmonella SteD, co-disinhibit WWP2 E3 ubiquitin ligase through distinct mechanisms.

DOI 10.1101/2025.04.23.650309

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedJun 21, 2024

Modulation of Salmonella virulence by a novel SPI-2 injectisome effector that interacts with the dystrophin-associated protein complex.

Xiu‐Jun Yu, Hai Xia Xie, Yan Li…·Teresa L. M. Thurston

This paper identifies a novel SPI-2 effector, SseM, in Salmonella that interacts with the dystrophin-associated protein complex and modulates bacterial growth in mice.

9 citations

mouseproteomics

𝕏 PostBluesky