Daniel J. Puleston

This study identifies Tetherin as an immunometabolic checkpoint in adipocytes that restricts type I interferon signaling while preserving glycolytic capacity, improving metabolic homeostasis.

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

This paper shows that AXL inhibits cholesterol mobilization in dendritic cells, which is necessary for their maturation and immunogenic response to cancer.

The paper introduces Compass, an algorithm that uses single-cell RNA-Seq and flux balance analysis to characterize metabolic states in Th17 cells, revealing a metabolic switch and novel anti-inflammatory regulators.