Matthew D. Park

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

This study shows dendritic cells enhance CAR T cell persistence in irradiated tumors by antigen-dressing and stimulating CAR T cells through chimeric receptors.

The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

This study identifies Serpinb2 and Serpine1 as key factors in pancreatic cancer that remodel the tumor microenvironment to promote immune evasion and tumor progression.

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.

This paper shows that AXL inhibits cholesterol mobilization in dendritic cells, which is necessary for their maturation and immunogenic response to cancer.

This study identifies circulating senescent myeloid cells as drivers of blood-brain barrier breakdown and neurodegeneration in LCH-ND.