Satdarshan P. Monga

The paper develops RIZLiver to infer zonal identity from gene expression in liver disease, showing loss of zone-3 identity in MASLD and therapeutic potential through zonal restoration.

This paper establishes two mouse models of Oropouche virus-induced hepatitis, showing that Type I interferons control disease severity and that contemporary isolates are less pathogenic than historical strains.

This study shows cyclin D1 regulates hepatic gene networks and metabolic responses to feeding, with non-cell cycle roles in aging, MASLD, and C. elegans overnutrition.

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

This study shows that inhibiting endothelial AGO1 reduces vascular inflammation and atherosclerosis by blocking its non-canonical nuclear role in promoting NF-κB-driven inflammation.

This study investigates the role of CRM1/HMGB1 nuclear translocation in T2D-driven MASLD and shows that inhibiting this pathway reduces HMGB1 release in T2D-NASH.

This paper develops a novel mouse model showing NOTCH1 drives temporal plasticity and metastasis in hepatocellular carcinoma through angiogenesis and TGFβ pathways.

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.