Vineet Agrawal

This study shows that reducing reactive lipids with 2-HOBA improves cardiac function and reduces pulmonary hypertension in mouse models.

This study uses spatial transcriptomics to analyze gene expression in heart transplant recipients during rejection, identifying distinct transcriptomic profiles associated with different rejection types and outcomes.

This study investigates the role of Nox4 in HFpEF-like remodeling in Pitx2 haploinsufficient mice, finding increased Nox4 expression and improved outcomes with GKT136901 treatment.

This study identifies a novel crosstalk mechanism between cardiomyocytes and adipocytes in obesity-associated HFpEF driven by natriuretic peptide-mediated inhibition of Wnt5a release from adipocytes.

This study shows that inhibiting salt-inducible kinases (SIKs) reduces weight gain and improves diastolic heart function in obese mice with heart failure with preserved ejection fraction (HFpEF).