Author

Brittany S. Leger

Massachusetts General HospitalORCID 0000-0002-8467-5472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Abraham A. PalmeriD· 2 shared James A. WalkeriD· 2 shared John J. MeredithiD· 2 shared Sandra Sanchez‐RoigeiD· 2 shared Alena L. BishopiD· 1 shared Alexander Samir HatoumiD· 1 shared Amit ChoudharyiD· 1 shared Amy C. JusticeiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenetics

Abraham A. PalmerORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

GeneticsAlcoholism Clinical and Experimental ResearchPeer-reviewedJun 21, 2024

Rare and Common Variants Associated with Alcohol Consumption Identify a Conserved Molecular Network

Brittany S. Leger, John J. Meredith, Trey E. Ideker…·Abraham A. Palmer

The paper identifies shared molecular networks between common and rare variants associated with alcohol consumption, revealing genes involved in alcohol metabolism and comorbid psychiatric traits.

2 citations

humanGWAS summary statistics

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Genetic & Genomic MedicinemedRxivPreprintMar 27, 2023

Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Sylvanus Toikumo, Mariela V. Jennings, Benjamin K. Pham…·Sandra Sanchez‐Roige

This study performs a multi-ancestry meta-analysis of tobacco use disorder using electronic health records, identifying 88 risk loci and 461 potential risk genes, and linking TUD to various health outcomes.

8 citations

humanelectronic health records

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NeurosciencePLoS GeneticsPeer-reviewedJan 19, 2021

HTT is a repressor of ABL activity required for APP induced axonal growth

Claire Marquilly, Germain U. Busto, Brittany S. Leger…·Jean‐Maurice Dura

The paper shows HTT represses ABL activity, which is necessary for axonal growth in Drosophila mushroom bodies.

14 citations

Drosophilaexperimental assay

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GeneticsCell ReportsPeer-reviewedJun 1, 2020

Small-molecule control of super-Mendelian inheritance in gene drives

Víctor López Del Amo, Brittany S. Leger, Kurt J. Cox…·Amit Choudhary

The paper describes a gene-drive system in Drosophila controlled by an engineered Cas9 and a synthetic small molecule to enable chemical control of inheritance.

49 citations

Drosophilaexperimental assay

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