ImmunologyBloodPeer-reviewed
Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells
Jonas Kath, Clemens Franke, Vanessa Drosdek…·Dimitrios L. Wagner
This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.
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