Author

Clemens Franke

Humboldt-Universität zu BerlinORCID 0009-0009-0476-2807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Carla Fuster‐GarcíaiD· 2 shared Dimitrios L. WagneriD· 2 shared Hans‐Dieter VolkiD· 2 shared Jonas KathiD· 2 shared Maik SteiniD· 2 shared Michael Schmueck‐HenneresseiD· 2 shared Petra ReinkeiD· 2 shared Toni CathomeniD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Carla Fuster‐GarcíaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologyMolecular TherapyPeer-reviewedFeb 3, 2025

Gene editing of CD3 epsilon gene to redirect regulatory T cells for adoptive T cell transfer

Weijie Du, Fatih Noyan, Oliver McCallion…·Dimitrios L. Wagner

This paper develops a non-viral CRISPR-Cas12a method to redirect Tregs with CARs by integrating an antigen-binding domain into the CD3 epsilon gene, showing improved antigen-specific function and graft protection in a mouse model.

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humanCITE-seq

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ImmunologyBloodPeer-reviewedMar 17, 2024

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

Jonas Kath, Clemens Franke, Vanessa Drosdek…·Dimitrios L. Wagner

This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.

55 citationstop 1%

humanproteomics

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