Jorge D. Lightfoot

This study shows that the Aspergillus fumigatus CreA repressor is critical for corneal infection by enabling hyphal invasion, while gluconeogenesis is not required for infection in lung or cornea.

This paper investigates the antifungal properties of 4μ8C, an Ire1 inhibitor, showing strong activity against Aspergillus fumigatus in vitro and in a fungal keratitis treatment model.

This study shows that hypoxia adaptation in Aspergillus fumigatus is essential for fungal keratitis, as a hypoxia-sensitive mutant failed to establish infection.