Michel Cogné

The paper shows that mucosal B cell memory selection diverges between lungs and gut, favoring MBCs and PCs respectively, driven by tissue-specific BCR isotype usage rather than affinity.

This study shows REL deregulation gives AID-imprinted B-cells a competitive advantage in germinal centers, promoting expansion and potential transformation into aggressive lymphomas.

The paper shows that locus suicide recombination (LSR) occurs in human B-cells during activation, targeting the IgH locus and leading to cell death.

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.