Ignacio Anegón

This study characterizes a rat model with a NFKB2 mutation, revealing systemic immunodeficiency with thymic and peripheral lymphoid defects.

This study identifies HIVEP3 as a critical regulator of thymic epithelial maturation and self-antigen expression, with its deficiency causing chronic inflammation.

This paper introduces a confined culture system to generate innervated human gut organoids that mature faster and support transplantation, enhancing engraftment and function.

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

This study generates T-cell progenitors from human pluripotent stem cells to produce functional thymocytes, demonstrating similarity to cord blood HSCs and DN3a thymocytes.