Christopher Anderson

This study uses single-cell RNA sequencing to analyze age and cell population-specific responses to SARS-CoV-2 infection in lung epithelial cells, identifying differences in innate immune signaling between pediatric and adult tissues.

The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.

The paper uses computer simulations to show that prior exposure to antigenically dissimilar strains can enhance cross-reactive antibody responses to conserved influenza HA regions, with implications for universal vaccine design.