Author

Maoshen Sun

Howard Hughes Medical InstituteORCID 0000-0002-8602-4817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1 Organism:yeast· 1

Frequent Co-Authors

Huasong AiiD· 3 shared Lei LiuiD· 3 shared Jia-Bin LiiD· 2 shared Lujun LiangiD· 2 shared Man PaniD· 2 shared Qiang ShiiD· 2 shared Xiangwei WuiD· 2 shared Yunxiang DuiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Huasong AiORCID

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3 papers

Recent·Most cited

Molecular BiologyScience AdvancesPeer-reviewedMay 30, 2025

Mechanistic Insights into the Stimulation of the Histone H3K9 Methyltransferase Clr4 by Proximal H3K14 Ubiquitination

Yunxiang Du, Maoshen Sun, Zhengqing Li…·Lei Liu

The paper determines the crystal structures of Clr4 bound to ubiquitinated and unmodified H3 peptides, revealing how H3K14 ubiquitination synergistically enhances Clr4 catalytic activity through conformational changes and multivalent interactions.

11 citations

yeastexperimental assay

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BiochemistryNature Chemical BiologyPeer-reviewedOct 11, 2024

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

Huasong Ai, Zebin Tong, Zhiheng Deng…·Man Pan

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

35 citationstop 4%

ChIP-seqstructural biology

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedJan 4, 2024

Synovial Sarcoma X Breakpoint 1 Protein uses a cryptic groove to selectively recognize H2AK119Ub Nucleosomes

Zebin Tong, Huasong Ai, Ziyu Xu…·Lei Liu

This study identifies a unique mechanism by which SSX1 recognizes H2AK119Ub nucleosomes through a cryptic groove, enabling specific hijacking of the BAF complex in synovial sarcoma.

41 citationstop 2%

humanproteomics

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