Huasong Ai

This study identifies a hierarchical anchoring-gating mechanism in the MSL complex that ensures specific H4K16 acetylation and reveals its role in chromatin accessibility and transcription.

This study identifies steric compatibility between BIRC6 and UBA6 as the mechanism enabling specific activation of BIRC6 by UBA6 over UBA1.

The paper determines cryo-EM structures of IMiDs in full CRL4CRBN complexes, revealing a cryptic interfacial pocket that enhances IMiD efficacy and neosubstrate specificity.

The paper determines the crystal structures of Clr4 bound to ubiquitinated and unmodified H3 peptides, revealing how H3K14 ubiquitination synergistically enhances Clr4 catalytic activity through conformational changes and multivalent interactions.

The paper identifies a unique mechanism by which ASXL1 K351 monoubiquitination enhances PR-DUB activity through structural stabilization, enabling efficient H2AK119Ub deubiquitination.

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

This study develops a chemical synthesis method to create polyubiquitylated linker histone H1.0, revealing its role in enhancing RNF168-mediated H2A ubiquitylation through structural and biochemical analysis.

This study identifies a unique mechanism by which SSX1 recognizes H2AK119Ub nucleosomes through a cryptic groove, enabling specific hijacking of the BAF complex in synovial sarcoma.