Kathryn S. Hatch

This study identifies 'unlatching' as a common mechanism for Parkinson's disease-associated LRRK2 variants, showing increased membrane localization and decreased S935 phosphorylation.

This paper elucidates the structural mechanisms by which LRRK2 is activated and autoinhibited, showing how mutations affect these processes and suggesting therapeutic strategies.

The paper shows that short 5' UTRs in viral mRNAs are recognized by the IFIT2-IFIT3 complex, leading to translation inhibition and antiviral activity.

This study develops a high-affinity DARPin that binds to LRRK2's WD40 domain, improving structural analysis and revealing its role in disrupting LRRK2 filaments and Rab8A phosphorylation.

The paper examines how APOE4 modifies the effect of plasma LDL on white matter integrity in older adults, finding a significant moderation effect.

The paper uses machine learning to predict brain age from diffusion tensor imaging in schizophrenia patients and finds accelerated white matter aging is associated with cognitive deficits.

This paper introduces a novel ℓ0 graph norm shrinkage algorithm for genetic fine-mapping, demonstrating improved sensitivity and reduced false positives in identifying causal variants for nicotine dependence.

The paper evaluates vertical and horizontal pleiotropy pathways linking genetic variants, white matter integrity, and nicotine dependence using UK Biobank data.