Daniel Hesselson

The paper presents analyses to assess selection dynamics in multi-round protein selection experiments, offering insights into diversity, coverage, and reproducibility.

This paper introduces PROTEUS, a chimeric viral platform for directed evolution in mammalian cells, demonstrating its ability to generate sensitive gene regulation tools and DNA damage-responsive nanobodies.

The paper characterizes cell-cell communication patterns in COVID-19 patients to identify differences between moderate and severe disease outcomes using single-cell RNA-seq data.

The paper shows the VEGAS platform for mammalian directed evolution is ineffective due to cheater particles that outcompete transgenes and prevent directed evolution.

This study identifies mCH accumulation at CAC trinucleotides in zebrafish brain development and shows Dnmt3a's role in mCAC deposition, demonstrating evolutionary conservation of mCH dynamics.

This paper uses a zebrafish model to study the in vivo effects of human A20 variants, showing that specific mutations impact A20 function and disease relevance.