Author

Nicholas Jason Roberts

Johns Hopkins UniversityORCID 0000-0002-8709-0664Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ralph H. HrubaniD· 2 shared Ajay V. MakeriD· 1 shared Aldo ScarpaiD· 1 shared Alyza M. Skaist· 1 shared Christine A. Iacobuzio–DonahueiD· 1 shared Claudio LuchiniiD· 1 shared Cristian TomasettiiD· 1 shared Davina Goodman· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Ralph H. HrubanORCID

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3 papers

Recent·Most cited

Cancer BiologyCancer CellPeer-reviewedAug 28, 2025

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct expression patterns and potential markers of progression

Yuefan Wang, T. Mamie Lih, Jae Woo Lee…·Ralph H. Hruban

This study profiles proteins and glycoproteins in pancreatic neoplasms to identify expression patterns and potential progression markers.

26 citationstop 1%

humanproteomics

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GeneticseLifePeer-reviewedApr 16, 2025

Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

Hirokazu Kimura, Kamel Lahouel, Cristian Tomasetti, Nicholas Jason Roberts

The paper functionally characterizes all CDKN2A missense variants and evaluates in silico pathogenicity models, finding 17.7% are deleterious and models have moderate accuracy.

3 citations

humanexperimental assay

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Cancer BiologyPLoS ONEPeer-reviewedDec 19, 2024

Islands of genomic stability in the face of genetically unstable metastatic cancer

Kirsten Bowland, Jiaying Lai, Alyza M. Skaist…·James R. Eshleman

The paper identifies genomically stable regions in metastatic pancreatic cancer that can be targeted by CRISPR-Cas9 due to preserved PAM sites, suggesting a potential gene therapy approach.

3 citations

humanwhole-genome sequencing

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