Corinne Maufrais

The paper develops and validates a 16-plex droplet digital PCR assay for accurate chromosome copy number quantification in C. albicans, showing strong correlation with whole-genome sequencing.

This study identifies Mnl1 as a repressor of azole tolerance in Candida albicans by linking it to sphingolipid metabolism, mitochondrial activity, and PKA signaling.

This study shows that altering BRG1 and CYR1 in a low-virulence C. albicans strain does not increase its virulence in vivo, suggesting complex gene networks regulate fungal pathogenicity.

This study maps 5' and 3' untranslated regions of Aspergillus fumigatus using experimental methods, revealing new regulatory elements and alternative transcription start and stop sites.

This study identifies polygenic determinants of fluconazole susceptibility, tolerance, and heteroresistance in Candida albicans using GWAS on 557 isolates, revealing distinct genetic loci and mechanisms.

The paper identifies a novel vesiculovirus, Mediterranean bat virus (MBV), circulating in bats across the Mediterranean region using a new RT-qPCR method and genomic analysis.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

The paper identifies widespread alternative TSS usage in Cryptococcus fungi in response to environmental cues and shows that the transcription factor Tur1 regulates this process genome-wide.

The paper investigates the transcriptome of extracellular vesicles in Cryptococcus neoformans using RNA sequencing and identifies small RNAs associated with these vesicles.

This study analyzes the genomic structure of Brazilian Cryptococcus isolates, revealing an African-like subclade distribution and identifying a mutator phenotype in one isolate.

The paper shows that start codon context regulates translation in fungi, affecting uORF usage and dual-protein localization.

The paper generates an ORFeome collection and associated tools for studying Candida albicans pathogenesis.