Darren Finlay

This paper identifies an acetylation-dependent circuit controlling SEC integrity in AML, showing that disrupting KAT2A/B leads to broad anti-leukemic effects across subtypes.

This study uses optical genome mapping to detect genomic rearrangements in gene-edited iPSCs, showing that transposons and lentiviral methods cause more insertions than CRISPR-Cas9.

This study identifies SUMO2 as a selective vulnerability in synovial sarcoma, showing that SUMO2 inhibition reverses SS18-SSX-driven gene expression and impairs tumor growth.

This study compares 3D tumoroid and 2D cultures of lung cancer cells to assess how cell-cell orientation affects cancer-related features and finds that 3D cultures better mimic primary human lung cancer.

This study shows MIR211 promotes melanoma growth and resistance to BRAF inhibitors by modulating the DUSP6-ERK5 axis via exosome transfer in the tumor microenvironment.