Molecular BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewed
Application of single nuclei RNA sequencing to assess the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
Rance Nault, Kelly Alana Fader, Sudin Bhattacharya, Tim R. Zacharewski
This study uses single nuclei RNA sequencing to identify cell-specific transcriptional changes and population shifts in mouse liver exposed to TCDD, revealing increased macrophages and RAS signaling in nonparenchymal cells.