Lian He

The paper inhibits striatal engrams involved in alcohol-taking behaviors to show reduced future alcohol-seeking and enhanced extinction.

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

This paper introduces light-controllable antibody mimetics, moonbody and sunbody, enabling rapid and reversible antigen recognition and precise control of cellular processes using light.

This paper describes engineered supramolecular organizing centers that enable light-controlled activation of innate immune responses through optogenetic manipulation of MyDDosome and MAVSome.