Author

Peter J.M. Valk

Erasmus MCORCID 0000-0002-8857-9461Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Peter J.M. Valk1 paper

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aditi VediiD· 1 shared Anja Krippner‐HeidenreichiD· 1 shared Bert A. van der ReijdeniD· 1 shared Branco M. H. HeutsiD· 1 shared Daan GilisseniD· 1 shared Elisa LaurentiiD· 1 shared Gladys Y. P. PooniD· 1 shared Jamie R. BlundelliD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Aditi VediORCID

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2 papers

Recent·Most cited

Cancer BiologyCell GenomicsPeer-reviewedJan 21, 2025

Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution

Gladys Y. P. Poon, Aditi Vedi, Mathijs Arnoud Sanders…·Jamie R. Blundell

This study uses single-cell DNA sequencing to analyze preleukemic hematopoietic stem cells and finds pervasive positive selection throughout preleukemic evolution, with selective advantages ranging from 9%-24% per year.

8 citationstop 4%

humanwhole-genome sequencing

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Cancer BiologyLeukemiaPeer-reviewedDec 4, 2024

The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia

Saioa Arza-Apalategi, Branco M. H. Heuts, Saskia M. Bergevoet…·Bert A. van der Reijden

The paper identifies HMX3 as a critical vulnerability in MECOM-negative KMT2A::MLLT3 AML, showing it promotes proliferation and blocks differentiation.

4 citations

humanbulk RNA-seq

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