Nico A. J. M. Sommerdijk

The paper shows that Fetuin-A mineral complexes exist in distinct states with different mineral bioavailability, controlled by chemical maturation.

The paper presents a correlative imaging workflow for multiscale structural and chemical analysis of mineralized tissues, revealing a plywood-like collagen architecture and phosphate-rich mineral platelets in zebrafish scales.

This paper presents a workflow combining organ-on-chip culture with 3D light and electron microscopy for microtissue analysis, demonstrating the feasibility of extended live imaging and focused ion beam/SEM for ultrastructural study.

This study shows that overglycosylation of collagen type I affects fibril structure by altering local packing and sub-band displacements without changing overall periodicity.

This study uses Raman and TEM to show whitlockite and carbonated hydroxyapatite in calcified aortic valves, challenging existing calcification models.

This study develops a 3D in vitro bone model to show osteoblasts organize collagen matrix alignment during early osteogenesis without osteoclast activity.

This study shows that cylindrical pores in collagen direct the uniaxial orientation of HAp crystals through confinement and anisotropic growth.