Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies
Rashmi P. Mohanty, Yuting Pan, Mae M. Lewis…·Debadyuti Ghosh
Peptide-conjugated immune checkpoint blockade antibodies show enhanced antitumor efficacy through electrostatic interactions with tumor ECM, increasing CD8+ T cell infiltration and reducing regulatory T cells.