Debadyuti Ghosh

Peptide-conjugated immune checkpoint blockade antibodies show enhanced antitumor efficacy through electrostatic interactions with tumor ECM, increasing CD8+ T cell infiltration and reducing regulatory T cells.

The paper identifies a peptide that enhances mRNA lipid nanoparticle delivery to CF lung epithelial cells, showing improved mRNA expression in vitro and in vivo.

This paper uses machine learning to predict the effectiveness of ionizable lipids for mRNA delivery, identifying the number of outside carbons as a key factor.

The paper identifies peptides that enhance drug delivery through mucus and epithelial barriers in CF patients using phage libraries and sequencing.

The paper uses M13 phage display to identify a neutral, hydrophilic peptide that enhances permeation through hyperconcentrated mucin.