Author
University Medical Center GroningenORCID 0000-0002-9069-2930Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Peter Graham Clark, Lea Emmy Timpen, Alexander Martin Heberle…·Daryl P. Shanley
The paper introduces tools for parameter estimation of biochemical networks using stability constraints, validated on MTOR network data from breast cancer cells.
Jennifer Kahlhofer, Nikolas Marchet, Kristian Zubak…·David Teis
The paper identifies TXNIP as a regulator of amino acid uptake during cellular quiescence by mediating endocytosis of the LAT1/SLC7A5 transporter.
Maria F. Suárez Peredo Rodríguez, Laura J. Jilderda, Catalina Gaviria Agudelo…·Floris Foijer
The paper shows that increased PRMT5-MEP50 complex activity helps aneuploid cancer cells survive by reducing protein aggregation and proteotoxicity.
Stefanie Egetemaier, Heike Chauvistré, Renáta Váraljai…·Alexander Roesch
This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.
Suraj A. Sharma, Roland Sauter, Madlen Hotze…·Ines Heiland
GEMCAT predicts metabolic changes from transcriptomics or proteomics data and validates them with metabolomics, demonstrating its utility in human cell lines and inflammatory bowel disease patients.
Tobias Kipura, Madlen Hotze, Alexa Hofer…·Marcel Kwiatkowski
The paper develops an automated workflow and dual-column U(H)PLC-MRM-MS method to rapidly quantify amino acids and tryptophan metabolites in human serum and plasma, applied to a prostate cancer study to identify biomarkers.
Alienke van Pijkeren, Anna-Sophia Egger, Madlen Hotze…·Marcel Kwiatkowski
This study compares proteome coverage and extraction efficiency of different solubilization agents in proteo-metabolome analysis using SPM-LLE and direct cell lysis.