Tamás Balla

The paper develops a nanobody that selectively blocks EFR3 recruitment of PI4KA by targeting TTC7B, reducing membrane recruitment and PI4P production.

The paper identifies a metabolic connection between PI4P and PA at the plasma membrane, showing how PI4P depletion increases PA levels through PS synthesis and RhoB activation.

This study shows that GPCRs regain G protein signaling without endocytosis by sorting into an AP2-positive plasma membrane compartment, regulated by PI(4,5)P2 and beta-arrestins.

The paper reports a cryo-EM structure of EFR3A bound to the PI4KA complex, revealing the molecular mechanism of PI4KA membrane recruitment and its regulation in human disease.

The paper uses electron microscopy to identify unique structural changes in cells after transfection with Lipofectamine 2000 and 3000, providing a method to distinguish successfully transfected cells.