Sumitabha Brahmachari

The paper develops an energy-landscape framework to study bacterial chromosome segregation, showing SMC complexes enable a mid-replication transition crucial for faithful segregation.

This paper models chromatin torsion and RNAP translocation to show how DNA supercoiling and nucleosome dynamics regulate transcription velocity and gene expression.

This study demonstrates a method using magnetic tweezers to detect single base pair mismatches in DNA by observing plectoneme pinning under specific conditions.