Samir Kumar Maji

This paper develops an RNA aptamer, 1R6, that targets synuclein and shows therapeutic potential in synucleinopathies by inhibiting aggregation and promoting disaggregation.

This study shows that protein/peptide hormones undergo phase separation at the TGN, forming amyloid-like structures that enable efficient storage and regulated release in secretory granules.

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

This study identifies two distinct α-synuclein fibril polymorphs with different structural and functional properties linked to prion-like behavior in Parkinson's disease.

This study investigates how the size of α-synuclein fibril seeds affects their amplification, cellular uptake, and toxicity, revealing distinct mechanisms for small and large seeds.

This study shows that α-synuclein undergoes liquid-liquid phase separation, which transitions to solid amyloid fibrils, contributing to Parkinson's disease pathogenesis.

This paper develops a data-driven mathematical model to understand amyloidogenesis dynamics and predict therapeutic strategies for neurodegenerative diseases.