Vishwajeeth Pagala

This paper develops an AI framework to interpret single-cell RNA-seq data from pediatric solid tumors, identifying tumor-specific surface antigen pairs for targeted therapies.

This study evaluates false discovery rate and statistical power in DIA proteomics using technical replicates and spike-in experiments, revealing discrepancies between nominal and true FDR and showing power dependence on fold change and abundance.

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

The paper investigates how linear ubiquitin chains affect the proteome in Drosophila by analyzing proteomic changes in flies expressing chains of different lengths.

This study identifies UBE2D/eff as critical for maintaining proteostasis and a youthful proteome during aging by regulating protein degradation and preventing aggregate accumulation.

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.