Sieglinde De Cae

This study uses a cell-specific hACE2 mouse model to investigate whether SARS-CoV-2 can directly infect endothelial cells, finding no evidence of productive infection or disease.

The paper develops a targeted LC-MS method to quantify SARS-CoV-2 spike protein expression and enables proteome profiling of infected cells.

This paper presents a yeast-based platform for producing stable and potent heavy chain-only antibodies, demonstrating its effectiveness with an anti-SARS-CoV-2 example.

The paper describes the development of a broadly neutralizing antibody, XVR011, effective against SARS-CoV-2 and its variants in animal models.