Kimheak Sao

This study shows that a human hip OA-associated Chadl variant causes intervertebral disc degeneration in mice, with changes in ECM and biomechanics.

This study shows that SDC4 deletion protects against disc degeneration in mice under increased spinal flexion by preserving notochordal features and modulating proteomic pathways.

This study shows that OPA1 maintains mitochondrial structure and metabolic functions in NP cells and chondrocytes, preventing age-related degeneration in mouse intervertebral discs and knee joints.

This study shows that SDC4 deletion in mice leads to reduced bone mass, altered biomechanical properties, and changes in intervertebral disc matrix composition and metabolism.