Susana M. Coelho

The paper identifies HELM, a LOV-domain protein essential for phototaxis in brown algae, and shows its role in light-directed movement and flagellar fluorescence.

This paper develops a CRISPR-Cas method for gene knock-out and endogenous protein tagging in the brown alga Ectocarpus, enhancing functional genomics capabilities.

The paper investigates the molecular basis of life stage identity and reproductive mode in kelp, showing asexual reproduction is conditional and suppressed by mating partners.

The paper investigates the maternal-to-zygotic transition in brown algae, finding that zygotic genome activation occurs immediately after fertilization without stable parental imprinting, suggesting evolutionary flexibility in embryogenesis.

This study identifies PKN as a female-specific protein in brown algae that mediates species-specific fertilization by enabling male-female recognition.

The paper uses linked-read whole-genome data to study reproductive isolation and hybridization patterns between two cryptic brown algal species, revealing polygenic genome-wide barriers to gene flow.

This study uses transcriptomic data from brown algae to show that regulatory evolution drives multicellular innovation despite conserved genome architecture.

The paper uses ribosome profiling to analyze translational regulation in Ectocarpus across developmental stages, finding widespread stage- and sex-specific control and post-transcriptional buffering.

This paper develops a high-efficiency, transgene-free CRISPR-Cas12 genome editing method for brown algae, applicable across multiple species and enabling functional genomics studies.

The paper presents a lineage-wide evolutionary analysis of 3D genome architecture and organization across brown algae, revealing conserved chromosomal features, lineage-specific rearrangements, and long-term co-evolution of centromeres and retrotransposons.

This study characterizes meiotic axis proteins in the brown alga Ectocarpus, revealing novel domain architecture and thermodynamic properties that suggest alternative HORMA domain regulation mechanisms compared to other eukaryotes.

This study characterizes the U and V sex chromosomes in red algae, revealing their evolutionary origin and structural features, and highlights their role in sex determination.

The paper examines chromatin regulation in brown algae, showing loss of canonical silencing systems and emergence of H3K79 methylation as a repressive mechanism.

The paper shows that endogenous viral elements in brown algae can reactivate, replicate, and transmit viruses, challenging the view of EVEs as inert.

The paper analyzes brown algal genomes to trace the origin and evolution of U/V sex chromosomes, revealing gene gain-driven evolution and the demise of these systems through hermaphroditism and gene hierarchy shifts.

The paper presents a chromosome-level genome assembly of Bostrychia moritziana, revealing genome size expansion and genetic adaptations in red algae.

The paper investigates sexual differentiation in a U/V sex chromosome system using giant kelp, identifying key genes and transcriptome changes associated with male and female development.

The paper maps the 3D chromatin structure of sex chromosomes in the brown alga Ectocarpus, revealing their spatial organization and links to gene expression and sex determination.

The paper investigates the presence of a molecular hourglass pattern in brown algae, finding it in developmentally complex species but not in simpler ones.

This study shows maternal tissue controls apical-basal patterning in kelp embryos through cell wall signals, with detachment disrupting development and increasing parthenogenesis.

This study investigates the genetic and molecular interactions between U and V sex chromosomes in the brown alga Ectocarpus across its life cycle, revealing developmental regulation and histone modifications in the diploid sporophyte stage.

This study investigates the role of transcription and translation in the early development of Ectocarpus gametes by inhibiting these processes and observing developmental outcomes.

The paper investigates the molecular mechanisms of asexual reproduction emergence in brown algae, finding convergent gene expression changes and a key autosomal locus associated with the loss of sex.

This study identifies the BASELESS gene as encoding a PP2A regulatory subunit essential for initial cell division and basal cell fate establishment in Ectocarpus.

The paper identifies 47 histone PTMs in the brown alga Ectocarpus, including a novel mark, and shows their stable patterns through the life cycle and association with gene expression.

The paper introduces instaGRAAL, a Hi-C-based scaffolder that improves chromosome-level genome assemblies for brown algae.

This study shows that TALE HD TFs regulate sporophyte development in two eukaryotic supergroups, indicating an ancient origin of this regulatory system.