Atsushi Kanoke

This study develops a multiscale circulation model of cerebral hemodynamics to simulate flow redistribution in the Circle of Willis under normal, anatomical variation, and stenosis conditions, revealing key collateral pathway activation patterns.

The paper predicts functional impairment in stroke models by analyzing connectivity changes and their relationship to motor and spatial memory function in rat brains.

This study uses two-photon microscopy to show that T2DM impairs collateral circulation and increases leukocyte adhesion after ischemic stroke, leading to poor recovery and worse outcomes.

This study identifies altered monocyte subsets and suppressed interferon signaling in T2DM mice, contributing to worsened stroke outcomes through immunosuppression and inflammation.