GeneticsbioRxivPreprint
Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency
Daisuke Ariyasu, Emika Kubo, Daisuke Higa…·Kimi Araki
The paper establishes an IGHD2 mouse model to study GH deficiency, finding reduced Ghrhr and Gh promoter activities due to decreased nuclear CREB3L2 levels, revealing a novel molecular mechanism.
DOI 10.1101/545384