Cancer BiologyeLifePeer-reviewed
TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma
Maojin Tian, Le Yang, Ziqian Zhao…·Peiqing Zhao
This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.
DOI 10.7554/elife.92741.4