Lake‐Ee Quek

This study shows that heat stress at different developmental stages in wheat causes distinct molecular and phenotypic responses, with stronger effects on grain set and composition at the trinucleate stage.

The paper identifies distinct glutamine metabolism in a subset of proliferating cells using pathway-centric metabolomic analysis of cancer and non-cancer cell lines.

The paper identifies a selective JNK inhibitor that blocks metastasis in triple-negative breast cancer by targeting metabolic pathways.

The paper shows CD38 mediates base exchange on NMN to produce NaMN, linking salvage and de novo NAD+ pathways.

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

This study reveals that fatty acid oxidation (FAO) in cancer cells primarily compensates for low glucose-derived acetyl-CoA by supporting mitochondrial metabolism through a malic enzyme-dependent shunt, rather than serving as a primary fuel source.

The paper shows that CPT1a regulates the uptake of extracellular fatty acids into mitochondria for cardiolipin remodeling in prostate cancer cells, despite these fatty acids being minor contributors to the TCA cycle.