Lisa M. Butler

This study shows that inhibiting de novo lipogenesis and supplementing with PUFAs suppresses prostate cancer progression by inducing oxidative stress and cell death.

STILL-13C maps lipid metabolic flux in intact human tissues using isotopic labeling and MSI, revealing spatial heterogeneity in lipid pathways and responses to inhibition.

This study identifies CBP/p300 as critical for DNA repair in prostate cancer and shows that targeting it enhances therapeutic response.

FixNCut is a reversible fixation and dissociation method that preserves RNA integrity and cellular composition in human and mouse tissues, enabling robust single-cell and spatial analyses.

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

The paper shows that CPT1a regulates the uptake of extracellular fatty acids into mitochondria for cardiolipin remodeling in prostate cancer cells, despite these fatty acids being minor contributors to the TCA cycle.

Head-to-head on serial prostate adenocarcinoma sections: Xenium gave higher sensitivity, wider dynamic range and closer agreement with snRNA-seq; CosMx segmented cells better out of the box.

This study introduces a method to generate high-quality single-nucleus transcriptomic data from FFPE samples using recent single-cell genomic technology.

This paper integrates multiple spatial-omics modalities in prostate cancer samples to reveal molecular heterogeneity and correlations between lipids and gene expression.

OzFAD uses ozonolysis with LC-MS to discover new unsaturated fatty acids in human samples, doubling identified plasma fatty acids and revealing non-canonical double bond positions.