Yasemin Sancak

The paper introduces ORCA, a method to isolate mitochondria associated with specific organelles, revealing distinct proteomes and functional roles at organelle contact sites.

This study identifies ER-localized ceramide accumulation as a driver of replicative senescence through impaired ceramide trafficking.

This study shows that mitochondrial calcium signaling regulates branched-chain amino acid catabolism and the urea cycle in fibrolamellar carcinoma through transcriptional control of metabolic genes.

This study identifies three factors contributing to MCUB-dependent inhibition of mitochondrial calcium uptake using cell lines and live-cell imaging.

Pooling Fiber-seq gDNA with concatenated MAS-Seq cDNA in one PacBio run gives phased genome, methylome, chromatin, and transcriptome, exposing four gene disruptions from one X;13 translocation.

This paper develops a first-in-field protocol for radiolabeling isolated mitochondria with Tc-99m agents and shows early feasibility of tracking transplanted mitochondria in vivo.

The paper identifies 2884 calcium-regulated proteins across human, mouse, and yeast proteomes using thermostability assays and reveals novel calcium engagement in metabolic enzymes and the spliceosome.

This study shows that mitochondrial Ca2+ clearance regulates insulin secretion by modulating plasma membrane Ca2+ entry in beta-cells.