Shweta Chitkara

This study identifies ER-localized ceramide accumulation as a driver of replicative senescence through impaired ceramide trafficking.

This study identifies acid sphingomyelinase (ASMase) as a key regulator of ceramide levels during necroptosis, showing that its inhibition reduces membrane permeability by impairing MLKL pore formation.

This study shows that ET-resistant breast cancer cells are more sensitive to ceramide-induced endoplasmic reticulum stress, mediated through TRAM1, leading to cell death.

This study identifies acylation sites on MLKL and shows that acylation at specific cysteines affects its membrane interaction and necroptosis activity.