James H. Eberwine

The paper analyzes mtDNA SNVs in single mitochondria from mouse neurons and astrocytes, revealing cell-type-specific mutation patterns and purifying selection.

The paper analyzes transcriptional burst kinetics in pyramidal and fast-spiking neurons to show that burst parameters differ from average mRNA counts and contribute to neuronal phenotype.

This paper introduces a high-throughput method for single-cell, single-mtDNA analysis using agarose-based droplet microfluidics, achieving high mtDNA retention and enabling scalable analysis.

CHEX-seq identifies open-chromatin regions in fixed single cells, enabling spatial chromatin analysis in complex environments.

The paper identifies dendritically localized mRNA isoforms in mouse neurons using sub-cellular RNA sequencing and provides a resource of known localized RNAs.