Xufeng Xue

This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.

This paper describes a transgene-free human embryo model that recapitulates peri-gastrulation development, including trilaminar embryonic disc and yolk sac-like structures.

This study develops a microfluidic hPSC-based model to control biochemical and biomechanical signals during somitogenesis, revealing their roles in somite formation.

The paper shows engineered substrates promoting cell-cell adhesion drive gastrulation-like self-organization in hESCs by enhancing cell tension and Wnt signaling to specify mesoderm.