Vladimir А. Gushchin

This study compares circular and linear mRNA vectors, finding linear vectors have higher expression levels but equal immunogenicity and protective activity.

This study evaluates the antiviral efficacy of SN_9, a prodrug of NHC, against orthopoxviruses in mice, showing significant survival and reduced disease severity.

This study establishes an IFN-deficient mouse model for CCHFV infection to evaluate pathogenicity and vaccine efficacy.

This study compares three TBEV vaccine candidates—mRNA-LNP, recombinant adenovirus, and YFV chimera—and finds the mRNA-LNP vaccine has higher immunogenicity and protective efficacy in mice.

This study develops a trivalent mRNA vaccine candidate for seasonal flu, showing higher immunogenicity and cross-specific humoral immune response compared to an inactivated split vaccine.

This study evaluates mRNA-LNP vaccines encoding SARS-CoV-2 structural proteins, finding that the S protein enhances immune responses to N protein, while M protein has low immunogenicity.

This study evaluates the lethality of different West Nile virus strains in a mouse model, highlighting the impact of amino acid substitutions on pathogenesis and vaccine development.

This paper develops an mRNA platform for delivering single-domain antibodies, achieving 100% protection against high doses of botulinum neurotoxin A in mice.

The paper isolates and characterizes three strains of Alongshan virus from Russian ticks, identifies novel genomic features, and confirms the utility of tick cell lines for virus maintenance.