Magdalena J. Ślusarz

This study investigates the membrane-dependent structure of CPXV012 and its interaction with TAP, revealing a two-helical organization and flexible ER-luminal region critical for TAP recognition.

This study identifies N-terminal electrostatic interactions in BoHV-1 UL49.5 as allosteric determinants of TAP degradation, showing that TAP degradation can be uncoupled from MHC class I downregulation.

This study identifies how BoHV-1 UL49.5 protein hijacks the C-degron pathway to promote TAP degradation via the CRL2 E3 ligase.