Niels Decher

This paper identifies a lower cytoplasmic gate in TALK-2 channels and demonstrates bidirectional coupling between this gate and the selectivity filter gate, showing that ion occupancy and stimuli can influence both gates.

This study investigates how mutations in POPDC proteins affect their heteromeric interaction and membrane trafficking, finding that complex formation is essential for membrane targeting.

This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.