Robert Blackwell

The paper compares methods for analyzing heterogeneity in TRPV1 cryo-EM data and finds that different methods detect different types of heterogeneity.

TM-Vec predicts structural similarity from sequence pairs to detect remote homologs, outperforming sequence alignment methods and matching structure-based alignment performance.

The paper introduces DeepBLAST, a method using protein language model embeddings to generate explicit sequence alignments, improving speed and accuracy for structurally similar proteins.