Venkatram R. Mereddy

This study synthesizes and evaluates glutathione-responsive niclosamide prodrugs as anticancer agents, showing reduced toxicity and tumor growth inhibition in mice.

The paper synthesizes nitroxoline analogs that inhibit MetAP2 and activate ATF4 via mTORC1, showing anti-cancer effects in vitro.

The paper synthesizes and evaluates novel mitochondrial pyruvate carrier inhibitors for cancer treatment, showing activity in vitro and metabolic plasticity inhibition.

This paper shows that silylating hydroxychloroquine improves its autophagy inhibition and antiproliferative effects in cancer cells.

This study designs and evaluates novel GSTP1/M2 inhibitors, finding that 5b effectively reduces tumor growth in vivo by overcoming gemcitabine resistance.

The paper develops novel fluoro-substituted aminocarboxycoumarin derivatives as mitochondrial pyruvate carrier inhibitors with anticancer potential.

This study combines mitochondrial-targeting anthelmintics with a GLUT1 inhibitor to target cancer metabolism, showing enhanced efficacy by disrupting both glycolysis and mitochondrial respiration in breast cancer cells.