William M. Old

The paper identifies eIF3d and eIF3e as mediators of hypoxia-induced translational control and shows that small molecules can inhibit this process.

This study shows CBD disrupts cholesterol homeostasis in human cell lines, altering metabolites, transcripts, and proteins related to cholesterol biosynthesis, transport, and storage.

The paper identifies and functionally characterizes MIPs lost in RIB72A/B knockout Tetrahymena cells using proteomics and cryo-electron tomography.

The paper identifies nuclear interactors of DYRK1A, revealing its role in DNA damage repair and providing a resource for further functional studies.

The paper introduces iTSA, an isothermal shift assay for rapid drug target identification, showing higher throughput and multiplexing compared to thermal proteome profiling.

This study uses cerebral organoid proteomics to identify dysregulated networks in trisomy 21 and shows harmine partially normalizes key developmental regulators.

The paper identifies a contaminant peptide in synthetic Amyloid-β42 that inhibits cytotoxicity and fibrillation.

The paper uses proteomics to identify early changes in AD model mice synaptosomes, finding significant proteomic alterations before traditional disease markers appear.