Harry S. Xenias

This study investigates how pathogenic LRRK2 mutations affect striatal physiology in mice, finding that R1441C causes motor learning deficits rescued by a kinase inhibitor, while G2019S does not.

This study identifies distinct GPe neuron subtypes using mouse lines and shows their unique roles in motor behavior and anxiety-like behavior through optogenetics and machine learning.

This study identifies distinct roles of PV+ and Npas1+ neurons in the GPe for locomotion and shows differences in their synaptic inputs from the STN in Parkinson's disease.

The paper identifies Npas1+-Nkx2.1+ neurons as a distinct subclass of GPe neurons and describes their role in the cortico-pallido-cortical loop.